June 15, 2024

A brand new report by Dutch scientists revealed a really peculiar case: On Feb. 2022, a 72-year-old man with a compromised immune system was admitted to Amsterdam College Medical Middle with a COVID-19 an infection. The virus in his physique proceeded to evolve over the course of 613 days, resulting in a extremely mutated variant that in the end killed him.

Based on the examine, the person, whose id was not disclosed, suffered from a blood dysfunction. Regardless of receiving a number of doses of the SARS-CoV-2 vaccine, his compromised immune system made him unable to generate a detectable antibody response, permitting the virus to proceed to evolve right into a “novel immune-evasive variant” that had mutated over 50 instances. The person died from his underlying blood dysfunction after preventing COVID for practically two years, the scientists from the College of Amsterdam’s Centre for Experimental and Molecular Medication said. 

“This case underscores the danger of persistent SARS-CoV-2 infections in immunocompromised people as distinctive SARS-CoV-2 viral variants might emerge because of in depth intra-host evolution,” the examine authors said in a press launch. “We emphasize the significance of constant genomic surveillance of SARS-CoV-2 evolution in immunocompromised people with persistent infections given the potential public well being risk of presumably introducing viral escape variants into the neighborhood.”

Whereas the examine notes there have been circumstances during which individuals have examined optimistic for COVID-19 for a whole lot of days, this case is the longest reported by far. Moreover, researchers say the uncommon variant discovered on this affected person hasn’t been reported in anybody else, however emphasize the necessity for extra examine to guard the general public from potential new variants.

The researchers say they plan to additional current this examine on the European Society of Medical Microbiology and Infectious Illnesses World Congress in Barcelona, Spain, beginning this weekend.   

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